Nitric oxide no is a pleiotropic free radical messenger molecule there is enzymatic non enzymatic and bacterial production of no in the human gut this book examines the role of no in human gastrointestinal and hepatic physiology and disease processes. 1 introduction11 nitric oxide no nitric oxide is a ubiquitous signaling molecule having an ability to freely diffuse across the cell membranes and unlike other classical neurotransmitters no cannot be regulated by storage release and reuptake process. Nitric oxide nitrogen monoxide is a molecule and chemical compound with chemical formula of n oin mammals including humans nitric oxide is a signaling molecule involved in many physiological and pathological processes it is a powerful vasodilator with a half life of a few seconds in the blood standard pharmaceuticals such as nitroglycerine and amyl nitrite are precursors to nitric oxide. Nitric oxide no is a ubiquitous water soluble free radical gas which plays key role in various physiological as well as pathological processes over past decades no has emerged as a molecule of interest in carcinogenesis and tumor growth progression however there is considerable controversy . Therapeutic role of nitric oxide as emerging molecule since the mid 1980s the development of new no donors has offered several advantages over theprevious no donors such as spontaneous
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